SKY-0515 is a daily oral drug designed to lower both huntingtin, the protein that drives HD, and PMS1, a DNA repair protein linked to somatic CAG repeat expansion. Researchers hope this dual-target ...
In a recent study, scientists created a chemical that breaks down expanded huntingtin HTT clumps in HD cells and mouse models. This chemical finds HTT clumps and targets them to be broken down or ...
Today, on June 17, 2026, uniQure shared a press release with an update from their recent Type B meeting with the FDA. In ...
Huntington’s disease (HD) involves the loss of cells in the striatum, an area of the brain that plays important roles in movement, cognition, and behaviour. For decades, researchers have been ...
A recent collaboration between researchers at the University of Leiden and the Huntington Expertise Center Topaz Overduin in the Netherlands has focused on an important yet often overlooked part of ...
Skyhawk Therapeutics has announced by press release new 12-month data from their Phase 1/2 trial of SKY-0515, an experimental oral treatment for Huntington’s disease (HD). The latest results largely ...
When your body makes new DNA, or fixes damaged DNA, it is assisted by a special protein called LIG1. If laying down DNA is like arranging a pattern of tiles, then LIG1 is the assistant who checks over ...
Last year, 329,000 people visited HDBuzz. They came after a clinical trial result they didn’t understand. After a conversation with a doctor that left them with more questions than answers. After a ...
In plain language. Written by scientists. ⏱️7 min read | In 2025, you helped us reach 329,000 people with independent, unbiased HD research news. Our 2025 Annual Report is here. Take a look at what we ...
In plain language. Written by scientists. A clinical trial for an exciting therapy against HD is planned for 2015. The first step is to make sure it is safe.
In plain language. Written by scientists. ⏱️13 min read | Australia just made history by banning life insurers from using genetic testing against you. But for HD families in other countries, the laws ...
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