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The need for clinical judgement in the application of evidence-based medicine

Correspondence to Professor J. David Spence, Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, ON, N6G 2V4, Canada; dspence{at}robarts.ca ...
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BMJ Evidence-Based Medicine

BMJ Evidence-Based Medicine (BMJ EBM) publishes original evidence-based research, insights and opinions on what matters for health care. We focus on the tools, methods, and concepts that are basic and ...
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Catalogue of bias: observer bias

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Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances

Objectives Alteplase is commonly recommended for acute ischaemic stroke within 4.5 hours after stroke onset. The Third European Cooperative Acute Stroke Study (ECASS III) is the only trial reporting ...
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Online First

Correspondence on ‘Less is more for patients, practitioners, public and planet: a taxonomy for the harms of too much medicine’ ...
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The effect of publication bias magnitude and direction on the certainty in evidence

Correspondence to Dr Mohammad Hassan Murad, Evidence-based Practice Center, Mayo Clinic, Rochester, MN 55905, USA; murad.mohammad{at}mayo.edu When decision makers make a recommendation based on ...
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Rapid reviews methods series: Guidance on literature search

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RR) use modified systematic review methods to accelerate the review process ...
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Evaluating data extraction error by a large language model from randomised controlled trials: a large-scale empirical study

Objective To examine the potential errors of a general large language model (LLM) (ie, Claude 3.5 Sonnet) on data extraction from randomised controlled trials (RCTs). Design and setting An empirical ...
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Equity and representativeness in pragmatic drug trials: methodological and ethical considerations

The WHO defines health equity as ‘the absence of unfair, avoidable or remediable differences among groups of people based on various dimensions of inequality (eg, sex, gender, ethnicity, disability or ...
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Advancing shared decision-making towards social justice: insights into an intersectional and decolonial approach from a Brazil–Canada partnership

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Uncovering seeding trials: examining non-scientific purposes in clinical trials

Seeding trials —clinical studies designed primarily for marketing rather than scientific advancement—pose underappreciated risks to research integrity and patient safety. Sukhun Kang and colleagues ...
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CARE extension guideline for acupuncture case reports

1 The Affliated Guangzhou Hospital of TCM of Guangzhou University of Chinese Medicine, Guangzhou, China 2 The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, ...