iAutoEvoLab is an industrial-grade automation platform for the growth-coupled, continuous evolution of proteins in yeast. Its high throughput, efficiency and effectiveness were demonstrated by the ...

Viewing protein evolution through the lens of complex systems theory may offer new insights into the principles driving biological adaptation. In this Comment we explore how characteristics such as ...

A research team has unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve. Rice University's Peter Wolynes and his research team have unveiled a ...

Landfills are overflowing with plastic trash. Serial inventor Jonathan Rothberg’s Protein Evolution found a solution: using AI to create enzymes that can recycle old polyester textiles into a material ...

Scientists have developed a novel protein evolution approach dubbed optovolution that uses light to guide the evolution of proteins with dynamic, multi-state, and computational functions based on ...

The number of known proteins is infinitely small in comparison to the universe of possible proteins, which could in theory be realized. Yet these known proteins are the only major training ground for ...

EvoRank offers a new and tangible example of how AI may help bring disruptive change to biomedical research and biotechnology more broadly. Using the MutRank framework trained with EvoRank, Danny Diaz ...

Overview of protein engineering strategies. Directed evolution mimics natural selection in the laboratory through iterative rounds of mutagenesis and screening. Rational design uses structural and ...

Evolution is biology’s powerful method of engineering. It works by generating many variants of DNA, RNA, and proteins inside cells and letting nature “select” the organism that performs best. Early ...

They identified specific pseudogenes, such as cyclophilin A, profilin-1 and small ubiquitin-like modifier 2 protein, where stabilizing mutations occurred in regions crucial for binding to other ...