Proteoforms, the diverse molecular variants of proteins, are key to understanding cellular functions, disease mechanisms, and ...

In genetics, one harmful variant can be enough to cause disease—but two can make it far more severe. One notable example is KJ, an infant diagnosed with a rare urea cycle disorder with a grim ...

Protein activity can be precisely regulated via subtle changes in temperature using heat-sensitive switches. Underlying this ...

Osaka, Japan – Our cells carry out hundreds of thousands of important functions every day, all of which are carefully orchestrated at a microscopic scale. However, the precise mechanisms that ...

Proteins are the 'workhorses' in every living cell and constitute the chemical basis of life. These little machines are required to turn food into energy, to manage motion and brain activities and to ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...

Johns Hopkins engineers have helped develop and characterize an artificial protein that triggers the same response in the human body as its natural counterpart—a breakthrough that not only has the ...

A research team led by Sahand Jamal Rahi at EPFL’s Laboratory of the Physics of Biological Systems has introduced a new ...

Cyanobacteria began contributing oxygen to Earth's mostly noxious atmosphere more than 2 billion years ago. The photosystem II protein complex now shared by various lineages of cyanobacteria, algae ...

Case Western Reserve University biochemical researchers have identified a new function of a key protein that leads to cancer—a finding they believe could lead to more effective treatments for a range ...