Asymmetric Friedel–Crafts reactions harness chiral catalysts to induce enantioselective carbon–carbon bond formation between activated arenes and electrophiles. Over the past two decades, advances in ...

The formation of chiral organic molecules from Friedel–Crafts reactions of chiral alcohols has been deemed impractical due to racemization via carbocation formation. Here we demonstrate the ...

Harvard University’s Emily P. Balskus, Hitomi Nakamura, and Erica E. Schultz have discovered an enzyme, dubbed CylK, that accomplishes this same transformation during the biosynthesis of ...

Thanks to the superstrength of the silicon-fluorine bond, chemists at the University of Zurich have developed a new incarnation of the venerable Friedel-Crafts reaction: intramolecular aryl-aryl ...